Charge Nero's gun and lock onto the leader of the three angels while dodging their attacks. Head to the ninth mission, skip past the cutscenes and wait until you're attacked by three angel enemies. Here's a great way to get some quick souls (400-1,100) in about a minute. NOTE: If you've already beaten the game on Son Of Sparta mode, use the Heaven or Hell mode for this to get the orbs faster as each enemy on the way to the crystal will only require one shot. The initial hit is worth around 3,500-4,000 orbs, then whatever orbs are given until the crystal breaks entirely. In the sword master style (RIGHT on the d-pad), repeatedly press CIRCLE (B). Using Dante start on Level 12 and work your way to the red crystal. Submitted by: XanTechie Easy Red Orbs on Level 12 Engage Devil Trigger and use the Devil Buster on him. Sanctus will instantly fall to the ground level and your devil arm can be used to pull him closer.
Once the bubble around him is gone, go into your items menu and use a Holy Water. Whenever you're fighting Sanctus, the fastest way to beat him is to first break his bubble, as he is invincible while it's around him it only takes about 4 hits.
Before fighting Sanctus, stock up on Holy Water you should have at least 4 or 5.